Cutting Edge: Antigen-Independent CD8 T Cell Proliferation

Proliferation Cutting Edge: Antigen-Independent CD8 T Cell

Cutting Edge: Antigen-Independent CD8 T Cell

Cutting edge: CD4+ T cell control of CD8+ T cell reactivity to a model tumor antigen.

Neoantigens resulting from the inherent genomic instability of tumor cells generally do not trigger immune recognition. Similarly, transfection of tumors with model Ags often fails to elicit CD8+ T cell responses or alter a tumor's growth rate or lethality. We report here that the adoptive transfer of activated Th1-type CD4+ T cells specific for a model tumor Ag results in the de novo generatio...

Cutting edge: cross-presented intracranial antigen primes CD8+ T cells.

The CNS is considered immune privileged due to the blood-brain barrier and the absence of conventional lymphatics. Nonetheless, T cell immune responses specific for CNS Ag have been documented. Where these events are initiated and what cellular mechanisms are involved remain unknown. In this study, we established an experimental mouse model to evaluate the requirements for priming CD8+ T cells ...

Cutting edge: intravascular staining redefines lung CD8 T cell responses.

Nonlymphoid T cell populations control local infections and contribute to inflammatory diseases, thus driving efforts to understand the regulation of their migration, differentiation, and maintenance. Numerous observations indicate that T cell trafficking and differentiation within the lung are starkly different from what has been described in most nonlymphoid tissues, including intestine and s...